If Kojima can reintroduce that unsettling, surreal and foreign feeling from the first 4 games, then couple that with the designs of Del Toro, this could be amazing.
I really enjoyed Downpour but it will be interesting to see the game in Kojima's hands - I wonder how much actual gameplay we'll get!.
On a side note - "actual player reaction" clips are never taken seriously so I wonder why some horror games keep bothering with them?